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| Abstract |
Damage to nucleic acids is particularly hazardous because the genetic information in genomic DNA, such as nuclear and mitochondrial DNA, can be altered. Damage accumulated in cellular DNAs often initi...ates programmed cell death, as well as mutagenesis. The former may cause degenerative diseases, and the latter may result in neoplasia and hereditary diseases. The accumulation of oxidative damage in cellular DNA or RNA is a result of the incorporation of oxidized nucleotides generated in nucleotide pools, as well as a result of their direct oxidation. Recent progress in studies of the sanitization of nucleotide pools, in addition to DNA repair, have revealed the significance of the oxidation of free nucleotides to be unexpectedly large, in comparison to the direct oxidation of DNA.show more
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| Table of Contents |
1. Oxidatively Generated Damage to Cellular DNA: Mechanistic Aspects, Jean Cadet, Thierry Douki, Carine Badouard, Alain Favier and Jean-Luc Ravanat || 2. Chlorination and Nitration of DNA and Nucleic Acid Components, Clare L. Hawkins, David I. Pattison, Matthew Whiteman and Michael J. Davies || 3. Prevention of the Mutagenicity and Cytotoxicity of Oxidized Purine Nucleotides, Yusaku Nakabeppu, Mehrdad Behmanesh, Hiroo Yamaguchi, Daisuke Yoshimura and Kunihiko Sakumi || 4. Nucleotide Incision Repair: An Alternative and Ubiquitous Pathway to Handle Oxidative DNA Damage, Sophie Couve'-Privat, Alexander A. Ishchenko, Jacques Laval and Murat Saparbaev || 5. OGG1: From Structural Analysis to the Knockout Mouse, Arne Klungland, Jon K. Laerdahl and Torbj?rn Rognes || 6. Processing of 3’-End Modified DNA Strand Breaks Induced by Oxidative Damage, Jason L. Parsons, Emma Boswell and Grigory L. Dianov || 7. Oxidative Damage and Promoter Function, David Mitchell and Rita Ghosh || 8. Oxidative DNA Damage and Telomere Shortening, Torsten Richter and Thomas von Zglinicki || 9. Oxidative Damage and Repair in the Mitochondrial Genome, Lene Juel Rasmussen and Keshav K. Singh || 10. The Role of Oxidative Damage to Nucleic Acids in the Pathogenesis of Neurological Disease, V. Prakash Reddy, Ayse Beyaz, George Perry, Marcus S. Cooke, Lawrence M. Sayre and Mark A. Smith || 11. Nucleic Acid Oxidation and the Pathogenesis of Cardiovascular Diseases, Maria Grazia Andreassi || 12. Oxidative DNA Damage and Carcinogenesis Ryszard Olinski, Marek Foksinski and Barbara Tudek || 13. The Physiological and Pathological Roles of Oxidative Damage to DNA in Relation to Life Stage, Alberto Izzotti || 14. Analysis of 8-Hydroxy-2’-Deoxyguanosine as a Marker of Oxidatively Damaged DNA in Relation to Carcinogenesis and Aging, H. Kasai, T. Hirano, K. Kawai, Y. Tsurudome, H. Itoh, D. Himeji and T. Horiuchi || 15. Oxidatively Damaged DNA and Inflammation, Peter C. Dedon and Marita C. Barth || 16. The Role of Antioxidants in the Prevention of Oxidative Damage to Nucleic Acids, Peter Møller and Steffen Loft
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