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Hypogonadism in the male can be defined as a decrease in either endocrine or spermatogenetic function of the testis or both. Its conditions are frequently classified as being either primary or seconda...ry dependending upon the site of the defect. Primary hypogonadism associated with abnormality of the testis may be subdivided into two groups, these caused by genetic or developmental defects and those related to acquired conditions. On the other hand, secondary hypogonadism refers to hypogonadism caused by abnormality of hypothalamic-pituitary function. The clinical features will depend on the age at onset, degree of hormone deficiency, coexistence of other pituitary-hormone deficiency, and the nature of the hypothalamic-pituitary lesion.show more
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