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Adult congenital heart disease is currently prevalent due to improved procedures of open heart surgery and perioperative intensive care. The present study aimed to investigate the health-related param...eters in adult patients with ventricular septal defect (VSD, n = 11) and tetralogy of Fallot (TOF, n = 13), which are representatives of congenital heart diseases. Age- and sex-matched participants of health check-up program were served as controls (n = 29). Somatic growth such as body weight (p = 0.038) and height (p = 0.009) was significantly poor in the TOF group relative to the control group, whereas blood pressure was equivalent among the three groups. Fasting glucose level in the TOF group was significantly elevated than that in two other groups (p ≤ 0.001), whereas total cholesterol level was significantly lower in the TOF group than that in the VSD group (p = 0.030) and the control group (p = 0.011). Considering fetal cyanotic stress and low cardiac output in TOF, these results were compatible with fascinating hypothesis of fetal origins of adult diseases such as diabetes.show more
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