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Purpose: The purpose of this study was to compare the levels of sex steroid hormones and sex hormone-binding globulin (SHBG) in type 2 diabetes mellitus (type2 DM) with and without metabolic syndrome ...(MS), and to investigate the relationships of component of MS to sex steroid hormones, SHBG, visceral (VFA) and subcutaneous fat area (SFA) , and predicted maximal oxygen uptake (V O_2max). Methods: The newly diagnosed Japanese post-menopausal type2 DM patients (n=27) classified by MS (n=14) or non-SM (n=13) were participated in this study. The MS is evaluated by WHO criteria. Results: Free and total testosterone levels in type2 DM with MS had significantly increased as compared with non-SM. On the other hand, the SHBG level in type2 DM with MS had significantly decreased as compared with non-MS. Independently of VFA evaluated by CT scan, we observed that diastolic blood pressure at resting was significantly associated with calculated free testosterone, dehydroepiandrosterone-sufate and SHBG, and that serum triglyceride was significantly associated with SHBG. Conclusions: We observed the profile of relative hyperandrogenism in post-menopausal type2 DM with MS. These results suggest that sex steroid hormones may be biomarker of the several metabolic variations influenced by metabolic syndrome.show more
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