Export Mendeley
＜Doctoral Thesis＞
Potent induction of IFN-γ production from cord blood NK cells by the stimulation with single-stranded RNA
| Creator | |
|---|---|
| Examiner | |
| Language | |
| Academic Year Conferred | |
| Conferring University | |
| Degree | |
| Degree Type | |
| Journal Title | |
| Volume | |
| Issue | |
| First Page | |
| Last Page | |
| Publication Type | |
| Access Rights | |
| JaLC DOI | |
| Related DOI | |
| Abstract | Natural killer (NK) cells play important roles in the innate immunity against viral infections. Although newborn infants are more susceptible to severe and recurrent viral infections than adults, the ...precise role of NK cells in the innate immunity against viral infections during neonatal period is not known. To clarify the functional characteristics of cord blood (CB) NK cells, we examined the capacity of CB NK cells to produce IFN-γ in response to the Toll-like receptor (TLR) ligands. We found that NK cells produced a large amount of IFN-γ by the stimulation with ssRNA, a TLR8 ligand, in the presence of IL-2, INF-γ and monocytes. Surprisingly, CB NK cells produced higher amount of IFN-γ than adult peripheral blood (APB) NK cells in this condition. IL-12 produced from monocytes by the stimulation with ssRNA was indispensable for the production of IFN-γ by NK cells. NK cells in cooperation with other innate immune cells may play more important role during the neonatal period than in adults in the host defense against viral infections by high capacity of IFN-γ production to compensate immature acquired immunity.show more |
| Table of Contents | Introduction Materials and Methods Results Discussion References |
Hide fulltext details.
| File | FileType | Size | Views | Description |
|---|---|---|---|---|
med2453
|
264 KB | 477 | 本文 | |
|
med2453_abstract
|
128 KB | 110 | 要旨 |
Details
| Record ID | |
|---|---|
| Peer-Reviewed | |
| Rights | |
| Keywords | |
| Report Number | |
| Number of Diploma | |
| Granted Date | |
| Date Accepted | |
| Faculty | |
| Notes | |
| Created Date | 2013.07.12 |
| Modified Date | 2023.12.08 |