Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry - Collections

＜journal article＞
Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry

Creator	Creator Name Kawakami, Ryosuke 川上, 良介カワカミ, リョウスケ Affiliation Affiliation Name Department of Molecular Biology, Graduate School of Medical Science, Kyushu University 九州大学大学院理学研究院生物科学部門
	Creator Name Shinohara, Yoshiaki 篠原, 良章シノハラ, ヨシアキ Affiliation Affiliation Name Division of Cerebral Structure, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies 自然科学研究機構・生理学研究所　大脳皮質機能研究系・脳形態解析
	Creator Name Kato, Yuichiro 加藤, 裕一郎カトウ, ユウイチロウ Affiliation Affiliation Name Department of Biology, Faculty of Sciences, Kyushu University
	Author PID K002261 Creator Name Sugiyama, Hiroyuki 杉山, 博之スギヤマ, ヒロユキ Affiliation Affiliation Name Department of Biology, Faculty of Sciences, Kyushu University
	Creator Name Shigemoto, Ryuichi 重本, 隆一シゲモト, リュウイチ Affiliation Affiliation Name Division of Cerebral Structure, National Institute for Physiological Sciences, School of Life Science, The Graduate University for Advanced Studies 自然科学研究機構・生理学研究所　大脳皮質機能研究系・脳形態解析
	Author PID K000722 Creator Name Ito, Isao 伊藤, 功イトウ, イサオ Affiliation Affiliation Name Department of Biology, Faculty of Sciences, Kyushu University 九州大学大学院理学研究院生物科学部門
Language	English
Publisher	American Association for the Advancement of Science
Date	2003-05-09
Source Title	Science
Vol	300
First Page	990
Last Page	994
Publication Type	Accepted Manuscript
Access Rights	open access
Related DOI	isIdenticalTo https://doi.org/10.1126/science.1082609
Related DOI	Science \|\| 300 \|\| p990-994
Related DOI	http://seibutsu.biology.kyushu-u.ac.jp/~neurosci/
Related URI	Science \|\| 300 \|\| p990-994
Related URI	http://seibutsu.biology.kyushu-u.ac.jp/~neurosci/
Related URI
Related HDL
Relation	Science \|\| 300 \|\| p990-994
Relation	http://seibutsu.biology.kyushu-u.ac.jp/~neurosci/
Abstract	Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of... N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain.show more

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File	FileType	Size	Views	Description
figure 7	pdf	1.76 MB	479	シナプス
figure 6	pdf	589 KB	488	マウス脳
figure 5	pdf	634 KB	435	ヒト脳
figure 4	pdf	6.16 KB	148	結果
figure 3	pdf	5.28 KB	166	反対側
figure 2	pdf	3.73 KB	191	同側
figure 1	pdf	92.2 KB	263	入力の種類と配置
press	pdf	113 KB	582	プレスリリース

Details

Record ID	18919
Peer-Reviewed	Refereed
Subject Terms	NR2B
	シナプス
	海馬
	Synapse
	Hippocampus
ISSN	0036-8075
NCID	AA00835277
Notes	九州大学の伊藤功助教授（大学院理学研究院）と岡崎国立共同研究機構・生理学研究所の重本隆一教授の研究グループは、脳の左半球と右半球は構造的にも機能的にも明確な違いがあることを、初めて分子レベルで明らかにした。脳の左半球は言語や論理的思考において、一方右半球は音楽や直感的思考において重要な働きをするなど、両者の機能が異なることは広く知られている。しかし、その機能的な違いと関連するような、構造的な違いが左右の脳にあるかどうかについては明確な証拠がなかった。今回の成果によりこの差を分子レベルで解析することが可能となり、左右脳機能の差を明らかにする具体的な手段を獲得した。（九州大学プレスリリースより）
Created Date	2011.02.02
Modified Date	2024.01.10

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＜journal article＞ Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry

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＜journal article＞
Asymmetrical Allocation of NMDA Receptor ε2 Subunits in Hippocampal Circuitry